Publications

  1. Zhao, J., Garcia, GA., Goldberg, AL. Control of proteasomal proteolysis by mTOR. Nature 2016 Jan 21;529(7586):E1-2. doi 10.1038/nature16472.
  2. Myeku, N, Kukushkin, N, Clelland, CL, Shaler, TA, Figueroa, Y, Herman, M, Kaiser, SE, Yu, WH, Goldberg, AL, and Duff, KA. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nature, 2016 Jan;22(1): 46-53. Doi:10.1038/nm.4011 
  3. Li, M, Kandror, O, Akopian, T, Dharkar, P, Woldawer, A, Maurizi MR, Goldberg, AL. Structure and functional properties of the active form of the proteolytic complex, ClpP1P2 from Mycobacterium tuberculosis. J Biol Chem, 2016 Apr 1;291(14):7465-76. Doi: 10.1074/jbc.M115.700344.
  4. Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brotz-Oesterhelt H. Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease. Mol Microbiol. 2016 Jul;101(2):194-209. Doi: 10.1111/mmi.13362
  5. Lee, DH., Sherman, MY., Goldberg, AL. The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins. Biochem Biophys Res Commun. 2016 Jun 17;475(1):100-6. Doi: 10.1016/j.bbrc.2016.0046.
  6. Zhao, J and Goldberg, AL. Coordinate regulation of autophagy and the ubiquitin proteasome system by mTOR. Autophagy. 2016 Oct 2;12(10):1967-1970. Doi: 10.1080/15548627.2011205770.
  7. Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Proc Natl Acad Sci USA. 2016 Aug 9;113(32):E4688-9 Doi: 10.1073/pnas. 1523597113.
  8. Alfred L. Goldberg: Probing the Proteasome. Trends Cell Biol. 2016 Sep 24. Pii: S0962-8924(16)30133-7. Doi: 10.1016/j.tcb.2016.09.003.
  9. Sha Z and Goldberg AL. Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation. Curr Biol. 2016 Sep 26;26(18):R836-7. Doi: 10.1016/j.cub.2016.08.030.
  10. Weyburne ES, Wilkins OM, Sha Z, Goldberg AL, Cole MD, Kisselev AF. Inhibition of the proteasome β2 site sensitizes triple-negative breast cancer cells to β5 inhibitors and suppresses Nrf1 activation. Cell Chem Biol. 2017; 24(2):218-230. Doi: 1016/j.chembiol.2016.12.016.
  11. Volodin A, Kosti I, Goldberg AL, Cohen S. Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization. Proc Natl Acad Sci U S A. 2017; 114(8):E1375-E1384. Doi: 10.1073/pnas.1612988114.
  12. VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L. Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia. 2018 Feb;66(2): 379-395. Doi: 10.1002/glia.23251. Epub 2017 Oct 27. PubMed PMID: 29076578
  13. Kim, HT and Goldberg, AL. The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis. J Biol Chem. 2017 Apr 17. Pii:jbc.M116.763128. Doi: 10.1074/jbc.M116.763128.
  14. Kuo, C-L and Goldberg, AL. Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c. Proc Natl Acad Sci U S A. 2017 Apr 25; 114(17):E3404-E3413. Doi: 10.1073/pnas.17017341
  15. Collins, GA and Goldberg, AL. The Logic of the Proteasome. Cell. 2017 May 18;169(5):792-806. Doi: 10.1016/j.cell.2017.04.023.
  16. VerPlank, J and Goldberg, AL. Regulating Protein Breakdown Through Proteasome Phosphorylation. Biochemical Journal. 2017. 474:3355-3371. Doi: 10.1042/BCJ20160809.
  17. Sha Z, Schnell HM, Ruoff K, and Goldberg AL. Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation. J Cell Biol. 2018; 217(5). Doi: 10.1083/jcb.201708168. PubMed PMID: 29535191
  18. Kim HT, Collins GA, and Goldberg AL. Measurement of the multiple activities of 26S proteasomes. In: The Ubiquitin Proteasome System: Methods and Protocols. Springer Nature. 2018; 1844: 289-308. Doi: 10.1007/978-1-4939-8706-1_19.
  19. Kuo CL, Collins GA, and Goldberg AL. Methods to Rapidly Prepare Mammalian 26S Proteasomes for Biochemical Analysis. In: The Ubiquitin Proteasome System: Methods and Protocols. Springer Nature. 2018; 1844: 277-288. Doi: 10.1007/978-1-4939-8706-1_18.
  20. VerPlank JJS and Goldberg AL. Exploring the regulation of proteasome function by subunit phosphorylation. In: The Ubiquitin Proteasome System: Methods and Protocols. Springer Nature. 2018; 1844: 309-319. Doi: 10.1007/978-1-4939-8706-1.
  21. Sha Z, Zhao J, and Goldberg AL. Measuring the overall rate of protein breakdown in cells and the contributions to the ubiquitin-proteasome and autophagy-lysosomal pathways. In: The Ubiquitin Proteasome System: Methods and Protocols. Springer Nature. 2018; 1844: 261-276. Doi: 10.1007/978-1-4939-8706-1_17.
  22. Weinhaupl K, Brennich M, Kazmaier U, Lelievre J, Ballell L, Goldberg AL, Schanda P, Fraga H. The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis. J Biol Chem. 2018 Jun 1; 293 (22): 8379-8393. Doi: 10.1074/jbc.RA118.002251.
  23. Lee D, Takayama S, Goldberg AL. ZFAND5/ZNF216 is a novel activator of the 26S proteasome that stimulates overall protein degradation. Proc Natl Acad Sci U S A. 2018; 115(41):E9550-E9559. Doi: 10.1073/pnas.1809934115.
  24. Kim HT and Goldberg AL. The UBL domain of Usp14 and other proteins stimulates proteasome activities and overall protein degradation in cells. Proc Natl Acad Sci U S A. 2018;115(50):E11650. Doi: 10.1073/pnas.1808731115.
  25. Fraga H, Rodriguez, Bardera A, Cid C, Akopian T, Kandror O, Park A, Colmenarejo G, LeLievre J, Goldberg AL. Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis. Analytical Biochemistry. 2019. 567: 30-37. Doi: 10.1016/j.ab.2018.12.004.
  26. VerPlank J, Lokireddy S, Zhao J, Goldberg AL. 26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation. Proc Natl Acad Sci U S A. 2019. Doi: 10.1073/pnas.1809254116.